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3-Amino- and 5-aminopyrazoles with anticonvulsant activity
H J Lankau1, M Menzer, A Rostock
1Corporate Research and Development ASTA Medica Group, Arzneimittelwerk Dresden GmbH, Radebeul, Germany.
Archiv Der Pharmazie
|July 10, 1999
Abstract:
New 3-amino- and 5-aminopyrazoles were synthesised. 3-Aminopyrazoles exert a strong anticonvulsant effect, 4-Chlorophenyl-3-(morpholin-4-yl)-1 H-pyrazole 2 distinctively blocks sodium channels and is strongly effective in the Maximal Electroshock Seizure (MES) test.