[Electrophysiological analysis of changes in peripheral nervous system in multiple sclerosis]

In order to analyse the peripheral disturbances repetitive stimulation test (RNS Test) and nerve conduction studies were done in 33 patients, 19 women and 14 men (mean age 38.2 years), with at least probable diagnosis of multiple sclerosis. In RNS Test the mean CMAP amplitude was significantly lower in comparison to the control group without any difference after 30 seconds of effort. Significant decrementing response was revealed at low rate of stimulation (2Hz) and incrementing response during tetanic stimulation. Significant lower mean amplitude of M wave in all investigated nerves was found in motor nerve conduction velocity test. Abnormal mean distal latency and motor conduction velocity were less common. The mean results of sensory conduction velocity test were similar to the control group.