Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cryosurgical effects on growing vessels.

A P Ladd1, F J Rescorla, J G Baust

  • 1Department of Surgery, Indiana University School of Medicine, Indianapolis, USA.

The American Surgeon
|July 10, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Re-purposing cryoablation: a combinatorial 'therapy' for the destruction of tissue.

Prostate cancer and prostatic diseases·2015
Same author

Mechanisms of cryoablation: clinical consequences on malignant tumors.

Cryobiology·2013
Same author

Temperature-dependent activation of differential apoptotic pathways during cryoablation in a human prostate cancer model.

Prostate cancer and prostatic diseases·2012
Same author

Use of 1,25α dihydroxyvitamin D3 as a cryosensitizing agent in a murine prostate cancer model.

Prostate cancer and prostatic diseases·2011
Same author

Integrin involvement in freeze resistance of androgen-insensitive prostate cancer.

Prostate cancer and prostatic diseases·2010
Same author

Cold-Storage of Synthetic Human Epidermis in HypoThermosol.

Tissue engineering·2009

Cryoablation of liver tumors in juvenile rats preserved animal growth and vascular patency. This study suggests cryosurgery may be a safe treatment option for children with hepatic malignancies.

Area of Science:

  • Pediatric oncology
  • Surgical innovation
  • Vascular biology

Background:

  • Cryosurgical treatment is effective for unresectable hepatic malignancies in adults.
  • Concerns exist regarding cryosurgery's impact on pediatric growth and adjacent structures.

Purpose of the Study:

  • To evaluate the effect of cryoablation on adjacent vascular structures in a growing animal model.
  • To assess the safety and efficacy of cryoablation in a juvenile murine model.

Main Methods:

  • Liquid nitrogen cryoablation was performed on the abdominal aorta with interposed liver tissue in juvenile Sprague Dawley rats.
  • Serial sacrifices were conducted over 120 days, with comparisons made to sham-operated controls.

Main Results:

Related Experiment Videos

  • Animal growth and aortic diameter paralleled sham controls throughout the study.
  • Histologic analysis revealed cryoablation-induced smooth muscle cell injury and media layer collapse, but elastin composition and aortic patency were maintained.
  • A thermal sink effect on the opposing aortic wall was observed.

Conclusions:

  • Cryoablation adjacent to the abdominal aorta in adolescent rats maintained vascular patency, animal growth, and structural function.
  • Despite cellular injury and wall remodeling, cryosurgery appears to be a potentially useful treatment adjunct in young subjects with hepatic malignancies.