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Expression of long-term potentiation of the striatum in methamphetamine-sensitized rats
T Nishioku1, T Shimazoe, Y Yamamoto
1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Abstract:
We examined the change of corticostriatal glutamatergic neuronal transmission in striatal slices of methamphetamine (MAP)-sensitized rats in vitro. Tetanic stimulation induced long-term depression (LTD) of the field potential in the striatum of saline-treated rats. However, it induced long-term potentiation (LTP) in the striatum of MAP-sensitized rats. This LTP was significantly suppressed by a N-methyl-D-aspartate (NMDA) receptor antagonist, aminophosphonovaleric acid (APV). These results suggest that LTP is expressed in the striatum of MAP-sensitized rats, and that NMDA receptors are indispensable for the LTP formation.