Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute myeloid leukemia with t(5;11): two case reports.

M Itoh1, T Okazaki, M Tashima

  • 1Department of Hematology and Oncology, Clinical Sciences for Pathological Organs, Graduate School of Medicine, Kyoto University, Japan.

Leukemia Research
|July 10, 1999
PubMed
Summary

Rare chromosome 5;11 translocations in acute myeloid leukemia cases showed monocytic features, hyperleukocytosis, and chemoresistance. These findings highlight unique genetic markers in specific leukemia subtypes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishment and characterization of bone marrow stroma-dependent leukemia cell line, HB-1.

International journal of hematology·1998
Same author

Drug analysis by capillary electrophoretic methods.

Biomedical chromatography : BMC·1998
Same author

[Evaluation of new therapeutic procedures in benign esophageal diseases].

The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi·1998
Same author

Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity.

Brain research·1998
Same author

Expression, purification, and reconstitution of receptor for pituitary adenylate cyclase-activating polypeptide. large-scale purification of a functionally active G protein-coupled receptor produced in Sf9 insect cells.

The Journal of biological chemistry·1998
Same author

Diagnostic and biological significance of sideroblastic erythropoiesis in the myelodysplastic syndromes.

International journal of hematology·1998

Area of Science:

  • Hematology
  • Cytogenetics
  • Oncology

Background:

  • Acute myeloid leukemia (AML) encompasses diverse subtypes with distinct genetic alterations.
  • Chromosomal translocations are key drivers in leukemogenesis, influencing disease presentation and treatment response.
  • Translocations involving chromosome 11q and 5q are infrequently reported in myeloid leukemias.

Observation:

  • Two cases of acute leukemia with rare t(5;11) translocations are presented.
  • One case of acute monocytic leukemia (AMoL) exhibited t(5;11)(q31;q23).
  • A second case of acute myelomonocytic leukemia (AMMoL) showed t(5;11)(q35;q13.1).

Findings:

  • Despite subtle differences in translocation breakpoints, both cases displayed significant monocytic morphology.

Related Experiment Videos

  • Both patients presented with hyperleukocytosis, indicating a high white blood cell count.
  • The leukemic cells demonstrated resistance to chemotherapy, posing a treatment challenge.

    • Implications:

    • The t(5;11) translocation may represent a distinct genetic subgroup within acute myeloid leukemia.
    • Understanding these rare translocations is crucial for accurate diagnosis and prognostication.
    • The observed chemoresistance underscores the need for exploring alternative therapeutic strategies for these specific leukemia subtypes.