Related Experiment Videos
Effect of age and carbon tetrachloride on cytokine concentrations in rat liver
L E Rikans1, L A DeCicco, K R Hornbrook
1University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA.
Mechanisms of Ageing and Development
|July 10, 1999
Abstract:
Interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) concentrations were measured in livers of young-adult and old rats administered carbon tetrachloride or vehicle. IL-1beta levels were higher and IL-6 levels were lower in old rats than in young-adult rats. Carbon tetrachloride treatment increased IL-1beta and decreased TNF-alpha and IL-6. The elevation in IL-1beta was diminished by aging. These results indicate that the increase in carbon tetrachloride hepatotoxicity that occurs in old age could be related to a dysregulation of inflammatory cytokines.