Jove
Visualize
Contact Us

Related Experiment Videos

Exercise-induced hyperventilation: a pseudoasthma syndrome.

A H Hammo1, M M Weinberger

  • 1University of Iowa Hospitals & Clinics, Iowa City, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|July 10, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of a noninstrumented disposable method for quantifying serum theophylline concentrations.

Pharmacotherapy·1998
Same author

Apparent decrease in population clearance of theophylline: implications for dosage.

Clinical pharmacology and therapeutics·1997
Same author

Placebo-controlled versus comparative studies of drug effects.

The Journal of pediatrics·1995
Same author

Equations for calculation of theophylline dose.

The Journal of pediatrics·1994
Same author

Why adulterate theophylline?

Annals of allergy·1993
Same author

Reassessing the therapeutic range for theophylline: another perspective.

Pharmacotherapy·1993
Same journal

A Retrospective Case Series of Unusual Natural History Phenotypes of Food Protein-Induced Enterocolitis.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Anaphylactic Shock Due to Contaminated Albuterol Nebulizer with an Asian Lady Beetle (Harmonia axyridis): A Case Report.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Associations between genetic ancestry and allergic outcomes at 10 years among Black children.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Five-Year Follow-up After Peach Sublingual Immunotherapy in LTP Syndrome.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Overlapping Mechanisms and Novel Biomarkers Define Asthma and COPD as a Spectrum of Airway Disease.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same journal

Real-World Variation in Post-Dose Supervision and Activity Restriction During Maintenance Cow's Milk Oral Immunotherapy.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Many children diagnosed with exercise-induced asthma may actually have hyperventilation causing chest tightness. This study reveals that symptoms like dyspnea during exercise can stem from hypocapnia without bronchospasm, indicating potential misdiagnosis.

Area of Science:

  • Pediatric Pulmonology
  • Exercise Physiology
  • Respiratory Medicine

Background:

  • Exercise-induced asthma is a common condition.
  • It typically responds well to inhaled beta2 agonists.
  • Atypical cases or treatment-resistant exercise-induced asthma warrant further investigation.

Purpose of the Study:

  • To investigate the physiological changes during exercise in patients with atypical or treatment-resistant exercise-induced asthma.
  • To differentiate between bronchospasm and other causes of exercise-related respiratory symptoms.
  • To identify underlying mechanisms in patients misdiagnosed with exercise-induced asthma.

Main Methods:

  • Studied 32 patients (aged 8-18) with prior exercise-induced asthma diagnoses.
  • Standardized treadmill exercise was performed without pre-exercise bronchodilator use.

Related Experiment Videos

  • Monitored spirometry, oxygen saturation, and end-tidal CO2 levels before and after exercise.

    • Main Results:

    • 11 patients with chest tightness showed minimal FEV1 decrease (<15%) but significant end-tidal CO2 decrease (mean 23.2%).
    • Only 4 patients exhibited clear bronchospasm (FEV1 decrease 18-22%) with typical symptoms.
    • 17 patients had neither reproduced symptoms nor significant physiological abnormalities.

    Conclusions:

    • Chest discomfort during exercise in some adolescents may be due to hypocapnia from hyperventilation, not bronchospasm.
    • These findings suggest a potential misdiagnosis of exercise-induced asthma in certain pediatric cases.
    • Distinguishing hyperventilation from bronchospasm is crucial for accurate diagnosis and treatment.