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Updated: Aug 13, 2026
Transduction of Human Cells with Polymer-complexed Ecotropic Lentivirus for Enhanced Biosafety
Published on: July 24, 2011
Interaction of human immunodeficiency virus-derived vectors with wild-type virus in transduced cells
A A Bukovsky1, J P Song, L Naldini
1Cell Genesys, Foster City, California 94404, USA.
Abstract:
The interaction of human immunodeficiency virus (HIV)-derived vectors with wild-type virus was analyzed in transduced cells. Vector transcripts upregulated by infection had no measurable effect on HIV type 1 (HIV-1) expression but competed efficiently for encapsidation, inhibiting the infectivity and spread of HIV-1 in culture and leading to mobilization and recombination of the vector. These effects were abrogated with a self-inactivating vector.
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