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06:34
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
Occupational allergy caused by carnation (Dianthus caryophyllus)
I M Sánchez-Guerrero1, A I Escudero, B Bartolom
1Allergy Unit, Hospital Rafael Méndez Lorca, Murcia; and the Research and Development Department, Bial-Aristegui, Bilbao.
The Journal of Allergy and Clinical Immunology
|July 10, 1999
Summary
Carnation (Dianthus caryophyllus) exposure can cause occupational respiratory symptoms like rhinitis and asthma. This IgE-mediated allergy is linked to specific carnation allergens.
Area of Science:
- Occupational Health
- Allergology
- Immunology
Background:
- Occupational respiratory symptoms from decorative flowers are rarely documented.
- Workers in carnation cultivation frequently experience rhinitis and asthma symptoms due to exposure.
Purpose of the Study:
- To determine if carnation-induced symptoms are IgE-mediated.
- To identify potential allergens responsible for carnation allergy.
Main Methods:
- Studied 16 symptomatic carnation workers, 15 non-exposed asthmatics, and 15 healthy controls.
- Performed skin prick tests, RASTs, SDS-PAGE, and immunoblotting.
- Conducted nasal and bronchial provocation tests, and measured peak expiratory flow.
Main Results:
- 15/16 symptomatic workers showed positive skin prick tests to carnation extract.
- 13/16 patients had positive nasal provocation tests; RAST results correlated significantly.
- Immunoblotting identified two major IgE-binding fractions (34 and 35 kd) in patient sera.
Conclusions:
- Carnation exposure is implicated in occupational allergy.
- The allergic mechanism is dependent on Immunoglobulin E (IgE).
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