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Updated: Aug 15, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
A tuberculosis screening and chemoprophylaxis project in children from a high risk population in Edmonton, Alberta
D Doering1, R Kocuipchyk, S Lester
1Capital Health, Regional Public Health TB Clinic, Edmonton, Alberta.
Abstract:
Current recommendations for tuberculosis control are to screen high risk populations and provide chemoprophylaxis for those infected. In Edmonton, Alberta, one strategy has been to identify and provide TB skin tests to newly arrived immigrant school age children from TB endemic areas. The difficulty has been in identifying these children in the school population. This article describes a process tried in 1993-94 to find a better approach and to determine the outcome of a concentrated effort at screening and follow-up of this population. Using this method, 1,146 students were TB skin tested using 5tu PPD: 15% showed significant reactions (10 mm), 89% were offered chemoprophylaxis, and 68% of those offered (84% of those accepting) completed 9 months of chemoprophylaxis. The success of this process was dependent on the dedicated follow-up provided by the specialty public health clinic devoted to the prevention and treatment of tuberculosis.
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