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Updated: Jul 15, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
[Epidemiological study of a tuberculosis case in a large manufacturing enterprise in Quebec]
M J Drolet1, R Boisvert, S Déry
1Régie régionale de la santé, Centre-du-Québec. marie.josee.drolet@msss.gouv.qc.ca
Objectives:
To determine the prevalence of tuberculosis infection related to a case of pulmonary and laryngeal tuberculosis in a workplace and to study PPD predictors.
Methods:
The Mantoux skin test (PPD) was offered to all potentially infected contacts. Participants were asked to answer a questionnaire.
Results:
Among 112 exposed employees, 92 (82.1%) were tested. At the 5 mm level, 65.2% of employees had positive tuberculin skin test (PPD). By controlling prior BCG and the degree of exposure, it showed a positive association between age and PPD (RC: 3.5; 95% CI: 1.25-10.03). When age and BCG were controlled, high exposure was statistically associated with PPD results (RC: 5.6; 95% CI: 1.25-24.68).
Conclusion:
The observed prevalence rate is probably related to the fact that the index case was very infectious and had contact in an enclosed area over a long period of time before withdrawal from work.
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