Related Experiment Video
Updated: Jan 10, 2026

Three-Dimensional Culture Assay to Explore Cancer Cell Invasiveness and Satellite Tumor Formation
Published on: August 18, 2016
Birth cohort effects underlying the increasing testicular cancer incidence in Canada
1Bureau of Reproductive and Child Health, Laboratory Centre for Disease Control, Ottawa, ON. shiliang_liu@hc-sc.gc.ca
Purpose:
To examine the pattern of testicular cancer incidence by age, time period and birth cohort since 1969 in Canada.
Methods:
In addition to analyses of the secular trends by age group and birth cohort separately, an age-period-cohort model and the submodels with standard Poisson assumptions were fitted to the data.
Results:
The overall age-adjusted incidence of testicular cancer increased in Canada, from 2.8 per 100,000 males in 1969-71 to 4.2 in 1991-93. The younger age groups showed much higher absolute incidence rates in the recent period compared with those in the early period. Age-period-cohort modelling of data restricted to males aged 20-84 years suggested that the observed increase in testicular cancer could be largely attributed to a birth cohort effect. A steady increase in risk was observed among men born since 1945; those born between 1959 and 1968 were 2.0 (95% CI, 1.5-2.6) times as likely to develop testicular cancer as those born between 1904 and 1913.
Conclusion:
The risk of testicular cancer has increased over time and changing exposure to environmental factors early in life may be responsible for this.
Related Concept Videos
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Cancer Prevention
Some...
Longitudinal Research
Infertility in Males
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Cancers Originate from Somatic Mutations in a Single Cell

