Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone scintigraphy in renal osteodystrophy.

P de Graaf, I M Schicht, E K Pauwels

    Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
    |December 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correlation between head and neck radiologists reporting on extranodal extension detected on radiological imaging: A head and neck cancer international group multinational study.

    Oral oncology·2026
    Same author

    Visual outcome including visual field defects after treatment of paediatric optic pathway glioma: A nationwide cohort study.

    Acta ophthalmologica·2025
    Same author

    Use of Diffusion-Weighted Imaging and <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography Combined With Computed Tomography in the Response Assessment for (Chemo)radiotherapy in Head and Neck Squamous Cell Carcinoma.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2018
    Same author

    The multilayered structure of the human corpus spongiosum.

    Histology and histopathology·2018
    Same author

    Recurrent Optic Perineuritis after Intranasal Cocaine Abuse.

    Neuro-ophthalmology (Aeolus Press)·2016
    Same author

    3D Orbital Reconstruction in a Patient with Microphthalmos and a Large Orbital Cyst-A Case Report.

    Ophthalmic genetics·2016

    Bone scintigraphy using Tc-99m HEDP effectively detects skeletal issues in patients with renal osteodystrophy. This sensitive imaging method reveals increased bone activity, even in normal-appearing scans, correlating with disease severity.

    Area of Science:

    • Nuclear Medicine
    • Nephrology
    • Skeletal Radiology

    Background:

    • Renal osteodystrophy is a common complication in patients undergoing maintenance hemodialysis.
    • Assessing skeletal involvement in these patients is crucial for management.
    • Traditional radiographic methods have limitations in early detection.

    Purpose of the Study:

    • To evaluate the efficacy of bone scintigraphy with Tc-99m HEDP in detecting renal osteodystrophy.
    • To compare quantitative bone scan findings with radiographic abnormalities and histological data.
    • To determine if bone scintigraphy can identify subclinical skeletal involvement.

    Main Methods:

    • Bone scintigraphy with Tc-99m HEDP was performed on 30 patients on maintenance hemodialysis.
    • Quantitative analysis of skeletal activity was conducted and compared to a normal control group.

    Related Experiment Videos

  • Hemodialysis was used to reduce background activity from absent renal excretion.
  • Histological confirmation of renal osteodystrophy was obtained for all participants.

    • Main Results:

    • Bone scintigraphy detected abnormalities in 83% of patients, significantly higher than radiographic findings (46%).
    • Skeletal lesions were more pronounced and detected earlier with scintigraphy.
    • Quantitative analysis revealed increased skeletal activity in all patients, even those with normal-appearing scans.
    • Total skeletal activity correlated well with the severity of renal osteodystrophy, influenced by osteomalacia and hyperparathyroidism.

    Conclusions:

    • Bone scintigraphy with Tc-99m HEDP is a highly sensitive diagnostic tool for skeletal involvement in renal osteodystrophy.
    • The method can detect subclinical disease and provides a quantitative index of severity.
    • Findings suggest scintigraphy is superior to radiography for early detection and assessment of renal osteodystrophy.