Related Experiment Video

Updated: Aug 15, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

New chemotherapeutic strategies for soft tissue sarcomas

S R Patel1, R S Benjamin

  • 1Department of Melanoma-Sarcoma Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA. spatel@notes.mdacc.tmc.edu

Seminars in Surgical Oncology
|July 14, 1999
PubMed

Insights

Advanced soft-tissue sarcomas remain largely incurable. Optimizing current treatments like chemotherapy and exploring novel therapies, including anti-angiogenic and differentiation strategies, are crucial while awaiting new advancements. Multidisciplinary clinical trials are essential for improving cure rates.

Area of Science:

  • Oncology
  • Medical Research

Background:

  • Advanced soft-tissue sarcomas present a significant challenge with limited curative options.
  • Current standard treatments (surgery, radiation, chemotherapy) offer modest impact on disease progression.

Purpose of the Study:

  • To review and discuss current treatment strategies for advanced soft-tissue sarcomas.
  • To highlight the importance of optimizing existing modalities and exploring novel therapeutic approaches.

Main Methods:

  • Discussion of dose-intensive chemotherapy regimens.
  • Exploration of emerging drug development for sarcoma treatment.
  • Review of anti-angiogenic and differentiation therapy concepts.

Main Results:

  • Standard treatments have a limited effect on advanced soft-tissue sarcomas.
  • Ongoing research focuses on novel drug discovery and targeted therapies.
  • Multidisciplinary clinical trials are vital for advancing treatment efficacy.

Conclusions:

  • Optimizing current therapies and integrating novel approaches are necessary.
  • Patient and physician participation in clinical trials is critical for improving outcomes in advanced soft-tissue sarcomas.

More Related Videos

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.