Inhibition of mouse ear edema by steroidal and triterpenoid saponins

Certain steroids and triterpenoids isolated from diverse plant families were known to possess anti-inflammatory activity. In the course of finding new anti-inflammatory natural products, some steroidal and triterpenoid saponins were isolated and evaluated for their anti-inflammatory activity using in vivo mouse ear edema test. At the oral dose of 100 mg/kg, several steroidal saponins and triterpenoid saponins such as hederagenin glycosides showed significant inhibition of ear edema (20-37% inhibition), though less potent than indomethacin and hydrocortisone.