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Evolving concepts of thyroid hormone action.

J H Oppenheimer1

  • 1Department of Medicine, University of Minnesota, Minneapolis 55466, USA.

Biochimie
|July 14, 1999
PubMed
Summary
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Thyroid hormone action is now understood to be mediated by triiodothyronine binding to nuclear receptors. Advances in cloning these receptors allow detailed analysis of thyroid hormone's physiological and pathological effects.

Area of Science:

  • Endocrinology
  • Molecular Biology

Background:

  • Thyroid hormone action concepts have evolved significantly over 25 years.
  • The role of triiodothyronine (T3) as the primary mediator is now established.

Purpose of the Study:

  • To review advances in understanding thyroid hormone action.
  • To highlight the impact of nuclear receptor identification and cloning.

Main Methods:

  • Review of scientific literature over the past 25 years.
  • Discussion of displacement studies identifying nuclear receptors.
  • Analysis of receptor cloning techniques.

Main Results:

  • Recognition of triiodothyronine as the key active thyroid hormone.
  • Identification and characterization of specific nuclear receptors for thyroid hormone.

Related Experiment Videos

  • Cloning of thyroid hormone receptor variants.

    • Conclusions:

    • Nuclear receptors are central to thyroid hormone action.
    • Cloned receptors facilitate detailed biochemical analysis of hormone effects.
    • This progress deepens understanding of thyroid hormone's physiological and pathological roles.