Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement-endothelial cell interactions: pathophysiological implications.

F Tedesco1, F Fischetti, M Pausa

  • 1Department of Physiology and Pathology, University of Trieste, Italy. tedesco@fc.univ.trieste.it

Molecular Immunology
|July 14, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic approach to fibromyalgia: a consensus statement on pharmacological and non-pharmacological treatment from the neuropathic pain special interest group of the Italian neurological society.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2025
Same author

Robot-assisted partial nephrectomy using the novel Hugo™ RAS system: Feasibility, setting and perioperative outcomes of the first off-clamp series.

Urologia·2024
Same author

Incidence of SARS-COV-2 infection among swimming athletes: data from real life in Apulia (Italy), July 2020/August 2021.

Annali di igiene : medicina preventiva e di comunita·2022
Same author

Which physical activity in patients affected by hypoparathyroidism? A review of the literature and practical recommendations.

Journal of endocrinological investigation·2022
Same author

Bispecific antibodies targeting tumor-associated antigens and neutralizing complement regulators increase the efficacy of antibody-based immunotherapy in mice.

Leukemia·2014
Same author

Cardiovascular risk stratification and management of patients with rheumatoid arthritis in clinical practice: the "EPIDAURO registry".

International journal of cardiology·2014
Same journal

Neutrophil elastase-SERPINB1 axis in epithelial responses: Cell death, inflammation and SERPINB1 dynamics.

Molecular immunology·2026
Same journal

Phillyrin alleviates pulmonary fibrosis via modulation of the TGF-β1/Smad and Nrf2/HO-1 signaling pathways.

Molecular immunology·2026
Same journal

m6A modification of LINC00458 enhances HMOX1 stability via ELAVL1 recruitment to promote ferroptosis and aggravate asthma.

Molecular immunology·2026
Same journal

Overexpression of Hes1 inhibits cigarette smoke-induced mitochondrial apoptosis in AT2 cells by activating the Pgc-1α/Tfam signaling pathway.

Molecular immunology·2026
Same journal

Progesterone promotes favorable pregnancy outcomes in recurrent spontaneous, abortion by attenuating NK Cell overactivation and upregulating the cAMP/PKA/CREB signaling axis.

Molecular immunology·2026
Same journal

Oleanolic acid alleviates hepatic fibrosis by inhibiting liver macrophage recruitment and polarization.

Molecular immunology·2026
See all related articles

The complement system significantly impacts endothelial cell function, influencing inflammation and vascular tone. Understanding these interactions is crucial for treating vascular diseases like atherosclerosis.

Area of Science:

  • Immunology
  • Vascular Biology
  • Cellular Physiology

Background:

  • Endothelial cell function is modulated by circulating and extravascular humoral factors.
  • Proteins of the complement system are key humoral factors influencing endothelial cells.

Purpose of the Study:

  • To review the interactions between the complement system and endothelial cells.
  • To discuss the functional consequences of these interactions on inflammation, coagulation, and vascular tone.
  • To explore implications in vascular diseases and potential therapeutic strategies.

Main Methods:

  • Literature review of scientific publications on complement system and endothelial cell interactions.
  • Analysis of functional consequences, disease implications, and therapeutic approaches.

Related Experiment Videos

Main Results:

  • The complement system extensively interacts with endothelial cells, affecting key physiological processes.
  • These interactions play a significant role in the pathogenesis of atherosclerosis, ischemia/reperfusion injury, and xenotransplantation.

Conclusions:

  • Complement-endothelial cell interactions are critical in vascular health and disease.
  • Targeting complement regulation offers potential therapeutic avenues for vascular pathologies.