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Gall bladder emptying in severe idiopathic constipation.

C Penning¹, H A Gielkens, J B Delemarre

¹Department of Gastroenterology-Hepatology, Leiden University Medical Centre, The Netherlands.

|July 14, 1999

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Slow transit constipation (STC) patients exhibit reduced gallbladder emptying due to impaired neural responsiveness, not hormonal issues. This suggests broader gastrointestinal motility problems beyond the colon in STC.

Area of Science:

Gastroenterology
Digestive system physiology
Motility disorders

Background:

Slow transit constipation (STC) is potentially linked to a panenteric motor disorder.
Investigating upper gastrointestinal motility in STC patients is crucial for understanding the condition.

Purpose of the Study:

To evaluate gallbladder motility in patients with STC compared to healthy controls.
To assess the response of gallbladder emptying to neural and hormonal stimulation.

Main Methods:

Gallbladder emptying was measured using ultrasonography.
Stimulation involved modified sham feeding (MSF) for neural-vagal response and cholecystokinin (CCK) for hormonal response.

Main Results:

STC patients had significantly reduced fasting gallbladder volume compared to controls.

Related Experiment Videos

Gallbladder emptying in response to MSF was significantly impaired in STC patients.

Gallbladder emptying in response to CCK was not significantly different between groups, though absolute volume reduction was smaller in STC patients.

Conclusions:

STC patients show impaired gallbladder response to vagal stimulation, indicating neural pathway dysfunction.
Normal response to CCK suggests hormonal pathways are intact.
Findings suggest gastrointestinal motility abnormalities proximal to the colon in STC, specifically impaired neural responsiveness.