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Related Experiment Videos

Age-related changes in bone turnover in men.

D Fatayerji1, R Eastell

  • 1Department of Human Metabolism and Clinical Biochemistry, Clinical Sciences Center, Northern General Hospital, Sheffield, United Kingdom.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|July 15, 1999
PubMed
Summary

Aging affects bone turnover in men, with hormonal changes like decreased IGF-I and sex hormones playing a key role. Bone turnover is highest in young men and lowest in middle age.

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Gerontology

Background:

  • Biochemical markers are crucial for understanding osteoporosis pathophysiology.
  • Limited research exists on bone turnover markers in aging men.
  • Hormonal regulation of bone turnover in men requires further investigation.

Purpose of the Study:

  • To investigate the impact of aging on bone turnover markers in healthy Caucasian men.
  • To identify specific hormones that may regulate bone turnover in this population.
  • To explore age-related differences in hormonal influence on bone metabolism.

Main Methods:

  • Studied 178 healthy Caucasian men aged 20-79 years, with 30 men per decade.
  • Analyzed bone turnover markers including intact propeptide of type I procollagen, osteocalcin, bone alkaline phosphatase, free deoxypyridinoline, and cross-linked N-telopeptides of type I collagen.

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  • Measured levels of Insulin-like Growth Factor-I (IGF-I), IGF binding protein-3, dehydroepiandrosterone sulfate, testosterone, estradiol, free androgen index, sex hormone binding globulin, and parathyroid hormone.

    • Main Results:

    • Bone turnover showed a quadratic age-related pattern, with nadirs in the 50s for most markers.
    • Bone turnover was highest in the third decade, lowest in the fifth and sixth decades, with a slight increase in the eighth decade.
    • Significant age-related decreases were observed in IGF-I, testosterone, and estradiol, while parathyroid hormone increased.

    Conclusions:

    • IGF-I and sex hormones are positively correlated with bone turnover, particularly in younger men.
    • The influence of IGF-I and sex hormones on bone turnover diminishes with age.
    • These findings highlight the complex interplay between aging, hormones, and bone metabolism in men.