gamma delta T-cells may interfere with a productive immune response in Plasmodium yoelii infections

Mice lacking alpha beta T-cells or gamma delta T-cells were infected with Plasmodium yoelii 17X NL (non-lethal) and followed for parasitaemia and cytokine production. While the parasitaemia in wild type mice resolved after reaching a peak value of 30 to 50%, it persisted in the -alpha beta T-cell mice until death. However, in the -gamma delta T-cell mice the peak parasitaemia was 12.5% of the levels seen in the wild type and -alpha beta T-cell mice and resolved faster than in the wild type mice. Higher levels of IL-10 and IFN-gamma were consistently found in the wild type and -gamma delta T-cell mice but not in the -alpha beta T-cell mice.