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Related Experiment Videos

Immunomodulatory effect of IM-133.

S K Mitra1, M Gupta, D N Sarma

  • 1R & D Centre, Himalaya Drug Company, Makali, Bangalore, India.

Phytotherapy Research : PTR
|July 15, 1999
PubMed
Summary

The polyherbal formulation IM-133 boosts cell-mediated immunity. This study shows IM-133 enhances immune responses in mice, particularly T-cell activity, suggesting non-specific immune stimulation.

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Area of Science:

  • Immunology
  • Pharmacology
  • Natural Products

Background:

  • The immune system's complexity necessitates understanding modulatory agents.
  • Polyherbal formulations offer potential therapeutic benefits due to synergistic effects.
  • Assessing the immunomodulatory capacity of novel formulations like IM-133 is crucial.

Purpose of the Study:

  • To investigate the immunomodulatory effects of IM-133, a polyherbal formulation.
  • To determine if IM-133 preferentially stimulates cell-mediated immunity (CMI) or humoral immunity.
  • To evaluate the impact of IM-133 on specific immune responses in vivo and in vitro.

Main Methods:

  • Mice were treated with IM-133.
  • Delayed type hypersensitivity (DTH) response was measured in vivo.
  • Splenocyte proliferation was assessed in vitro following mitogenic challenge.
  • Ex vivo lymphocyte proliferation was evaluated after in vivo treatment.
  • Humoral response to sheep red blood cells (SRBCs) was measured.

Main Results:

  • IM-133 treatment significantly enhanced the DTH response in mice.
  • In vitro splenocyte proliferation in response to mitogens was increased by IM-133.
  • In vivo IM-133 administration stimulated ex vivo lymphocyte proliferation.
  • The humoral immune response to SRBCs remained unaffected by IM-133 treatment.

Conclusions:

  • IM-133 demonstrates significant immunomodulatory properties.
  • The formulation preferentially stimulates components of cell-mediated immunity.
  • IM-133 acts as a non-specific immune stimulant, enhancing cellular immune responses.

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