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Clonazepam in the treatment of prolonged depression
1Department of Psychiatry, Kawasaki Medical School, Kurashiki, Japan.
Background:
The purpose of this paper was to examine the optimal adjunctive dose of clonazepam for the treatment of prolonged depression.
Methods:
Sixty nine patients with prolonged depression were enrolled in an open trial over a 4 week period during which clonazepam was added to their medication.
Results:
A daily dose of 3.0 mg clonazepam as augmentation was significantly more effective than doses of 1.5 mg and below. Most of the improved patients showed a rapid onset of action within 2 weeks, and side effects were not severe.
Conclusion:
A daily dose of at least 3.0 mg clonazepam as augmentation of ongoing antidepressant treatment should be considered in prolonged depressive patients with suboptimal improvement.
Limitations:
The effect on clonazepam alone on prolonged depression was not established, and its effect of on severe depression is unknown. High dose treatment was not carried out in this study.
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