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Association of cervical artery dissection with recent infection

A J Grau1, T Brandt, F Buggle

  • 1Department of Neurology, University of Heidelberg, Germany. ArminvGrau@med.uni-heidelberg.de

Archives of Neurology
|July 15, 1999
PubMed

Insights

Recent infection is significantly linked to cervical artery dissection (CAD), a common cause of stroke in young adults. This association appears independent of mechanical factors often accompanying infections.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Vascular Medicine

Background:

  • Cervical artery dissection (CAD) is a primary cause of ischemic stroke in younger individuals.
  • The underlying etiology of CAD remains incompletely understood.

Purpose of the Study:

  • To investigate the hypothesis that recent infection is a frequent precursor to CAD.
  • To determine if an association exists between recent infections and the occurrence of CAD.

Main Methods:

  • A comparative study involving 43 acute CAD patients and 58 control patients (younger than 50 with other causes of cerebral ischemia).
  • Prevalence of infection in the preceding week was assessed.
  • Subgroup analysis included electron microscopy of skin biopsies and investigation of potential infection-CAD pathways.

Main Results:

  • A higher prevalence of recent infection was observed in CAD patients (58.1%) compared to controls (32.8%; P=.01).
  • Respiratory tract infections were most common in both groups.
  • Multivariate analysis confirmed recent infection, not mechanical factors like coughing or vomiting, as independently associated with CAD.

Conclusions:

  • The study indicates a significant association between recent infection and cervical artery dissection.
  • This link is not attributable to mechanical stressors associated with infections.
Abstract

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