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Conception rates after abortion with methotrexate and misoprostol
1Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Hospital, PA, USA. mcreinin@mail.magee.edu
Summary
Women undergoing medical abortion using methotrexate and misoprostol face a high risk of unintended pregnancy. Fertility returns quickly, emphasizing the need for effective contraception post-procedure.
Area of Science:
- Reproductive Health
- Pharmacology
Background:
- Medical abortion using methotrexate and misoprostol is a common method for early pregnancy termination.
- Understanding post-abortion fertility is crucial for family planning and preventing unintended pregnancies.
Purpose of the Study:
- To assess the fertility of women within one year after medical abortion.
- To determine the rate of unintended pregnancies following methotrexate and misoprostol abortion.
Main Methods:
- A cohort of women from a medical abortion clinical trial were followed for up to 12 months.
- Fertility information, including sexual activity, contraception use, and pregnancy outcomes, was collected via interviews.
Main Results:
- Of 114 women, 93 (81.6%) were contacted for follow-up, with a median follow-up of 11 months.
- During the follow-up period, 23 (24.7%) women became pregnant unintentionally.
- Pregnancy outcomes included one term delivery, one spontaneous abortion, and multiple elective abortions.
Conclusions:
- Women treated with methotrexate and misoprostol for early abortion have a high risk of subsequent unintended pregnancy.
- Rapid return of fertility necessitates diligent use of contraception after medical abortion.