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Pharmacokinetic interaction between acetaminophen and lansoprazole.
M Sanaka1, Y Kuyama, S Mineshita
1Department of Internal Medicine, School of Medicine, Teikyo University, Tokyo, Japan.
Journal of Clinical Gastroenterology
|July 15, 1999
Summary
Acetaminophen, a common pain reliever, is absorbed faster when taken with lansoprazole. This interaction speeds up acetaminophen absorption but does not significantly alter its overall bioavailability or elimination.
Area of Science:
- Pharmacology
- Drug Interactions
- Gastroenterology
Background:
- Acetaminophen is a preferred analgesic for patients with gastric acid-related disorders due to low gastric toxicity.
- Proton pump inhibitors like lansoprazole are frequently prescribed, increasing the likelihood of co-administration with acetaminophen.
Purpose of the Study:
- To investigate the pharmacokinetic interaction between acetaminophen and lansoprazole.
- To determine if lansoprazole affects the absorption, distribution, metabolism, and excretion of acetaminophen.
Main Methods:
- A crossover study involving six healthy male volunteers.
- Participants ingested 1.0 g acetaminophen alone and with 30 mg lansoprazole after a 2-day pretreatment.
- Plasma acetaminophen concentrations were measured over 8 hours.
Main Results:
- The peak plasma concentration of acetaminophen was significantly higher when co-administered with lansoprazole.
- The time to reach peak acetaminophen concentration was significantly shorter with lansoprazole.
- No significant differences were observed in acetaminophen's elimination half-life or area under the curve.
Conclusions:
- Lansoprazole significantly hastens the absorption rate of acetaminophen solution.
- Lansoprazole has minimal impact on the elimination rate and bioavailability of acetaminophen.
- The findings suggest a pharmacokinetic interaction affecting acetaminophen absorption, not elimination.