Audiogenic seizure sensitivity in mouse lines genetically selected for high versus low blood magnesium levels

The MGH and MGL mouse lines, genetically selected for high and low blood magnesium (Mg) levels, respectively, exhibit marked differences for characteristics expected to be related to blood Mg levels, such as increased stress sensitivity and stress-induced aggressivity in MGL mice. However, although Mg deficiency experimentally induced by low oral Mg intake has been shown previously to increase susceptibility to audiogenic seizures, MGL were less sensitive to audiogenic seizures than MGH mice. The MGH-MGL lines may, therefore, provide a beneficial and complementary model for the study of the relationships between audiogenic seizures and blood Mg levels.