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Cellular neurothekeoma with possible neuroendocrine differentiation
1Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
The Journal of Dermatology
|July 16, 1999
Summary
This study details a rare cellular neurothekeoma case with unique immunohistochemical results. The tumor displayed neuroendocrine and fibroblastic features, suggesting a diverse cell origin for this dermal neoplasm.
Area of Science:
- Dermatopathology
- Surgical Pathology
- Oncology
Background:
- Cellular neurothekeoma is a rare benign neoplasm of uncertain differentiation.
- Typical immunohistochemical markers often include S100 and Factor XIIIa positivity.
Observation:
- A 48-year-old woman presented with a 1 cm asymptomatic dermal nodule on her left upper arm.
- Histopathology revealed a dermal proliferation of spindle-shaped cells with eosinophilic cytoplasm.
Findings:
- Immunohistochemistry showed negativity for S-100, CD34, and Factor XIIIa, but strong positivity for neuron-specific enolase (NSE), synaptophysin, and chromogranin A.
- Ultrastructural analysis indicated undifferentiated mesenchymal cells with neuroendocrine and fibroblastic/myofibroblastic features.
Implications:
- This case highlights unusual immunohistochemical findings in cellular neurothekeoma, challenging typical diagnostic criteria.
- The findings suggest that cellular neurothekeoma may arise from undifferentiated cells with divergent differentiation potential, possibly including neuroendocrine and mesenchymal lineages.