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Gene related to stroke in stroke-prone spontaneously hypertensive rats
1Otsuka Department of International Preventive Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Japan.
Clinical and Experimental Pharmacology & Physiology
|July 16, 1999
Abstract:
1. In order to study genes related to stroke in stroke-prone spontaneously hypertensive rats (SHRSP), linkage analysis was performed using F2 rats (SHRSP/Izm x WKY/Izm). The brainweight that reflected cerebral stroke in F2 rats showed cosegregation with three genetic markers, D4Mit19 (P < 0.0015), D4Mgh7 (P < 0.0014) and D4Mgh8 (P < 0.004) on chromosome 4, but not blood pressure. 2. These results suggest that a chromosomal region other than the region responsible for hypertension contributes to the development of stroke in SHRSP.