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Lymphatic absorption of phytosterol oxides in rats
A Grandgirard1, J P Sergiel, M Nour
1Unité de Nutrition Lipidique, INRA, Dijon, France. grandgirard@dijon.inra.fr
Lipids
|July 16, 1999
Abstract:
Two of the main classes of oxyphytosterols (7-keto and epoxides) were synthesized from sitosterol and campesterol and given to mesenteric duct-cannulated adult male rats. Lymph was collected during 24 h and was analyzed for oxysterols. The results showed that the lymphatic recovery of the phytosterol oxides was low: 4.7% of the given dose for epoxy derivatives and 1.5% for 7-keto compounds. The campesterol oxides presented a better absorption than the sitosterol oxides. During the process of absorption, the epoxyphytostanols were also partly transformed in campestanetriol and stigmastanetriol.