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Synthesis and identification of conformationally constrained selective MMP inhibitors
J N Freskos1, J J McDonald, B V Mischke
1Department of Medicinal Chemistry, Searle Discovery Research, St Louis, MO 63198, USA.
Bioorganic & Medicinal Chemistry Letters
|July 16, 1999
Abstract:
We have discovered a new series of potent conformationally constrained MMP Inhibitors that are selective for MMP-13 over MMP-1.
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