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Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory
L Strekowski1, O Zegrocka, M Henary
1Department of Chemistry, Georgia State University, Atlanta 30303, USA.
Bioorganic & Medicinal Chemistry Letters
|July 16, 1999
Abstract:
On the basis of a systematic SAR analysis of substituted quinolines, a derivative 32 was synthesized that shows half-maximal inhibition of the immunostimulatory effect of CpG-oligodeoxynucleotides in vitro at the concentration of 0.24 nM.