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Synthesis of water-soluble phenytoin prodrugs
1Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Spain. jbosch@farmacia.far.ub.es
Bioorganic & Medicinal Chemistry Letters
|July 16, 1999
Abstract:
The synthesis of novel water-soluble phenytoin derivatives, bearing an ionizable group, and a preliminary study for in vitro blood hydrolysis are reported. The results show that hydrolysis of amino esters 8 is very fast, much more than that of fosphenytoin.