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Metallic surface modification.

I De Scheerder1, E Verbeken, J Van Humbeeck

  • 1Department of Cardiology, Gasthuisberg, University Hospital Leuven, Belgium.

Seminars in Interventional Cardiology : SIIC
|July 16, 1999
PubMed
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Electrochemical polishing significantly reduced stent thrombogenicity and neointimal hyperplasia in animal models. This surface treatment offers a promising approach for improving stent performance and patient outcomes.

Area of Science:

  • Biomaterials Science
  • Cardiovascular Research
  • Medical Device Engineering

Background:

  • Stent implantation can trigger thrombogenicity and neointimal hyperplasia, leading to adverse clinical events.
  • Optimizing stent surface properties is crucial for enhancing biocompatibility and reducing complications.
  • Electrochemical polishing is a surface treatment method with potential to modify metal stent characteristics.

Purpose of the Study:

  • To evaluate the impact of electrochemical polishing on the thrombogenicity of metal stents.
  • To assess the effect of electrochemical polishing on neointimal hyperplasia following stent implantation.
  • To determine the efficacy of this surface treatment in preclinical animal models.

Main Methods:

  • Stent thrombogenicity was assessed in a rat arteriovenous shunt model using radiolabeled fibrinogen and platelets.

Related Experiment Videos

  • Clot weight, fibrinogen deposition, and platelet deposition were quantified.
  • Neointimal hyperplasia was evaluated in a porcine coronary artery model after stent implantation.

    • Main Results:

    • Electrochemical polishing significantly reduced total clot weight and 125I-fibrinogen deposition in the rat model (p<0.001).
    • Platelet deposition showed no significant reduction with polished stents.
    • Neointimal hyperplasia was significantly decreased in polished stents compared to non-polished controls in the porcine model (p<0.01).

    Conclusions:

    • Electrochemical polishing effectively reduces stent thrombogenicity, particularly fibrinogen deposition.
    • This surface treatment demonstrates a significant benefit in mitigating neointimal hyperplasia.
    • Electrochemical polishing presents a viable strategy for improving the hemocompatibility and biological response of medical stents.