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Updated: Aug 9, 2026

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host
Published on: July 28, 2010
The human immune response during cutaneous leishmaniasis: NO problem
M D Mossalayi1, M Arock, D Mazier
1Hematology Laboratory, Faculty of Pharmacy Paris V, 4 Avenue de l'Observatoire, 75006 Paris, France. Djavad.Mossalayi@umr5540.u-bordeaux2.fr
Abstract:
During some helminth infections, increased expression of the low-affinity receptor for IgE (CD23/FcepsilonRII) by macrophages and/or increased levels of plasma IgE have been seen, but their role in host protection or disease progression remains unclear. Recently, crosslinking of CD23 was shown to promote intracellular killing of Leishmania parasites in human macrophages, a phenomenon involving the production of tumor necrosis factor alpha and nitric oxide (NO). Based upon various in vitro and in vivo studies of human cutaneous leishmaniasis, Djavad Mossalayi, Michel Arock, Dominique Mazier, Philipe Vincendeau and Ioannis Vouldoukis here propose a model for an immune response that involves CD23-IgE-mediated NO release during protection, as well as during active cutaneous leishmaniasis.
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