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TGF-beta Family Members and Gonadal Development
1Unité de Recherches sur l'Endocrinologie du Développement (INSERM), Ecole Normale Supérieure, Département de Biologie, 1 rue Maurice-Arnoux, 92120 Montrouge, France.
Trends in Endocrinology and Metabolism: TEM
|July 17, 1999
Abstract:
Several members of the transforming growth factor beta (TGF-beta) family are involved in gonadal development; namely, TGF-beta itself, inhibins, activins, anti-Müllerian hormone (AMH) and GDF-9. These proteins do not affect initial gonadal organogenesis but play either a stimulatory or inhibitory role in the division and differentiation of gonadal cells and in meiotic maturation in the female. Furthermore, as shown by transgenic mouse technology, both AMH and inhibin act as tumor suppressors.