Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Beyond proteins.

B Robson1

  • 1Computational Biology Center, IBM T. J. Watson Research Center, 30 Saw Mill River Road, Hawthorne, NY 10523, USA. robsonb@us.ibm.com

Trends in Biotechnology
|July 17, 1999
PubMed
Summary
This summary is machine-generated.

Scientists aim to create novel non-protein molecules and smart materials by understanding protein folding. A deeper grasp of topological principles, not just computing power, is key to achieving this goal.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glass box machine learning for retrospective cohort studies using many patient records. The complex example of bleeding peptic ulcer.

Computers in biology and medicine·2024
Same author

Towards faster response against emerging epidemics and prediction of variants of concern.

Informatics in medicine unlocked·2022
Same author

Techniques assisting peptide vaccine and peptidomimetic design. Sidechain exposure in the SARS-CoV-2 spike glycoprotein.

Computers in biology and medicine·2020
Same author

The use of knowledge management tools in viroinformatics. Example study of a highly conserved sequence motif in Nsp3 of SARS-CoV-2 as a therapeutic target.

Computers in biology and medicine·2020
Same author

Bioinformatics studies on a function of the SARS-CoV-2 spike glycoprotein as the binding of host sialic acid glycans.

Computers in biology and medicine·2020
Same author

COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles' heel conserved region to minimize probability of escape mutations and drug resistance.

Computers in biology and medicine·2020
Same journal

Bacterial spores as a modular platform for the production of amyloids for materials.

Trends in biotechnology·2026
Same journal

The oriGen case and Mexico's regulatory blind spots in genomic biobanking.

Trends in biotechnology·2026
Same journal

A caspase-3-activated protein expression system for apoptosis visualization and apoptosis-pyroptosis conversion to boost antitumor activity.

Trends in biotechnology·2026
Same journal

Over 4 months of ethylene production using solid-state photosynthetic cell factories.

Trends in biotechnology·2026
Same journal

Closing the nitrogen loop in groundwater with biohybrid technologies.

Trends in biotechnology·2026
Same journal

Engineering environmental bacteria for whole-cell PET hydrolysis and assimilation.

Trends in biotechnology·2026
See all related articles

Area of Science:

  • Biochemistry
  • Materials Science
  • Polymer Chemistry

Background:

  • Advances in understanding protein structure and folding, alongside protein-synthetic chemistry, offer opportunities to mimic biological molecules.
  • Current limitations exist in creating robust, novel materials that depart significantly from natural protein structures.

Purpose of the Study:

  • To explore the potential of creating non-protein molecules and molecular devices inspired by biological proteins.
  • To identify the fundamental requirements for developing advanced 'smart' polymers and materials that move beyond protein-like forms.

Main Methods:

  • Leveraging fundamental physicochemical principles to address the protein-folding problem.
  • Investigating the role of topological principles in molecular design.

Related Experiment Videos

Main Results:

  • The study suggests that mimicking protein structures can lead to new molecular devices.
  • Achieving radical departures into novel materials necessitates solving the protein-folding problem from basic principles.

Conclusions:

  • A deeper understanding of topological principles is crucial for developing advanced, non-protein-based smart materials.
  • Future innovations in materials science may arise from applying fundamental physicochemical and topological insights to molecular design, rather than relying solely on computational power.