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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
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After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

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Related Experiment Video

Updated: May 12, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Tissue factor in atherosclerosis.

E Tremoli1, M Camera, V Toschi

  • 1Institute of Pharmacological Sciences, E. Grossi Paoletti Center, University of Milan, Italy. Elena.Tremoli@unimi.it

Atherosclerosis
|July 17, 1999
PubMed
Summary
This summary is machine-generated.

Tissue factor (TF) is crucial in atherosclerosis and thrombosis, leading to heart attack and stroke. Understanding TF

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Last Updated: May 12, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

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Published on: May 6, 2014

Extracellular Vesicle Tissue Factor Activity Assay
03:53

Extracellular Vesicle Tissue Factor Activity Assay

Published on: December 29, 2023

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets
10:08

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Published on: November 22, 2024

Area of Science:

  • Cardiovascular Biology
  • Thrombosis Research
  • Atherosclerosis Pathogenesis

Background:

  • Thrombosis is central to atherosclerosis development and complications like myocardial infarction and stroke.
  • Vessel wall thrombogenicity, blood components, and lipid interactions influence thrombotic events.
  • Acute thrombosis can complicate arterial interventions such as bypass surgery and stenting.

Purpose of the Study:

  • To review the role of tissue factor (TF) in atherogenesis.
  • To highlight current knowledge on TF's involvement in plaque thrombogenicity.
  • To focus on potential pharmacological strategies targeting TF in atherosclerosis.

Main Methods:

  • Literature review of existing research on tissue factor and atherosclerosis.
  • Analysis of studies investigating TF presence in human coronary artery specimens.
  • Discussion of pharmacological interventions targeting the coagulation pathway.

Main Results:

  • Tissue factor (TF) is a key cellular cofactor initiating coagulation.
  • Active TF is found in human coronary arteries, associated with lipid areas, macrophages, and smooth muscle cells.
  • These findings suggest TF significantly contributes to atherosclerotic plaque thrombogenicity.

Conclusions:

  • Tissue factor plays a critical role in the thrombotic nature of atherosclerotic plaques.
  • Further research into TF's function is essential for developing targeted therapies.
  • Pharmacological inhibition of TF represents a promising therapeutic avenue for atherosclerosis.