Related Experiment Video
Updated: Jul 25, 2026

12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Myocarditis and primary Sjögren's syndrome
Lancet (London, England)
|July 17, 1999
Summary
Autoimmune myocarditis can cause congestive heart failure in patients with primary Sjögren's syndrome. Corticosteroid treatment effectively resolved the patient's symptoms and laboratory abnormalities.
Area of Science:
- Cardiology
- Rheumatology
- Immunology
Background:
- Primary Sjögren's syndrome is a systemic autoimmune disease primarily affecting exocrine glands.
- Cardiac involvement in Sjögren's syndrome is rare, with autoimmune myocarditis being an uncommon manifestation.
Observation:
- A case of congestive heart failure was observed in a patient diagnosed with primary Sjögren's syndrome.
- The heart failure was attributed to autoimmune myocarditis, an inflammatory condition of the heart muscle.
Findings:
- The patient presented with symptoms and laboratory findings consistent with congestive heart failure.
- Corticosteroid therapy was initiated for the autoimmune condition.
- Treatment with corticosteroids led to the resolution of both cardiac symptoms and laboratory abnormalities.
Implications:
- This case highlights the importance of considering autoimmune myocarditis as a cause of heart failure in patients with primary Sjögren's syndrome.
- Early diagnosis and prompt immunosuppressive treatment, such as corticosteroids, may be crucial for managing cardiac complications in this patient population.
- Further research is warranted to understand the mechanisms and prevalence of cardiac involvement in Sjögren's syndrome.
More Related Videos
Related Concept Videos
Other Disorders of Digestive System
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Pericarditis II: Clinical Features and Diagnostic Tests
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
Personality Theory by Eysenck and Eysenck
Hans and Sybil Eysenck developed a widely recognized theory of personality, which emphasizes the role of temperament and genetically based differences in shaping individual traits. Their theory posits that biological factors primarily determine personality and can be understood through two main dimensions: extroversion/introversion and neuroticism/stability.
In the extroversion/introversion dimension, highly extroverted people are sociable, outgoing, and easily connect with others. In contrast,...
In the extroversion/introversion dimension, highly extroverted people are sociable, outgoing, and easily connect with others. In contrast,...
Psychoneuroimmunology: Cardiovascular Disease
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...

