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Hypoxic hypometabolism in the anesthetized turtle, Trachemys scripta.

J W Hicks1, T Wang

  • 1Department of Ecology and Evolutionary Biology, University of California, Irvine, California, USA. jhicks@uci.edu

The American Journal of Physiology
|July 17, 1999
PubMed
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Hypoxia induces a regulated hypometabolic state in turtles, independent of oxygen availability. This metabolic adaptation may prolong aerobic dive times by reducing oxygen consumption.

Area of Science:

  • Comparative Physiology
  • Environmental Physiology
  • Vertebrate Metabolism

Background:

  • Hypometabolism is observed in vertebrates during hypoxia.
  • The regulatory mechanisms and O(2) dependence of this response are not fully understood.

Purpose of the Study:

  • To determine the metabolic response of turtles to normocapnic and hypercapnic hypoxia.
  • To test if hypoxic hypometabolism is a regulated response independent of O(2) availability.

Main Methods:

  • Measurements of metabolic rate (VO(2)), cardiovascular function, and blood gases in anesthetized turtles.
  • Exposure to varying levels of inspired O(2) (normocapnic hypoxia) and O(2) with added CO(2) (hypercapnic hypoxia).
  • Pharmacological challenge with 2,4-dinitrophenol to assess metabolic regulation.

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Main Results:

  • Hypoxia reduced O(2) consumption (VO(2)) by nearly 30% in turtles.
  • Normocapnic hypoxia did not significantly affect VO(2); adding CO(2) did not enhance hypoxia effects.
  • 2,4-dinitrophenol increased VO(2) during hypercapnic hypoxia, counteracting hypoxic effects.

Conclusions:

  • Hypoxia induces a hypometabolic state in anesthetized turtles, which is likely a regulated response.
  • This hypometabolism does not appear to be solely due to limited O(2) availability at the cellular level.
  • Hypoxemia from cardiac shunts during diving may trigger this hypometabolic state, prolonging aerobic dive times.