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Related Experiment Videos

Prostatic growth and development are regulated by FGF10.

A A Thomson1, G R Cunha

  • 1Anatomy Department, Box 0452, University of California, San Francisco, San Francisco CA 941434-0452, USA. axel.thomson@ed-rbu. mrc.ac.uk

Development (Cambridge, England)
|July 20, 1999
PubMed
Summary
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Fibroblast Growth Factor 10 (FGF10) acts as a paracrine regulator of epithelial growth in the rat ventral prostate and seminal vesicle during development. FGF10 expression is crucial for early organ formation and neonatal growth, independent of androgen regulation.

Area of Science:

  • Developmental Biology
  • Endocrinology
  • Molecular Biology

Background:

  • Fibroblast Growth Factor 10 (FGF10) is implicated in organ development.
  • The role of FGF10 in prostate and seminal vesicle development requires further elucidation.
  • Understanding FGF10's function can provide insights into reproductive organogenesis.

Purpose of the Study:

  • To investigate the role of FGF10 in the growth and development of the rat ventral prostate (VP) and seminal vesicle (SV).
  • To determine if FGF10 gene expression is regulated by androgens.
  • To assess the effect of FGF10 on prostatic and seminal vesicle epithelial cell growth and organ development.

Main Methods:

  • Analysis of FGF10 transcript abundance during rat VP and SV development.

Related Experiment Videos

  • In vitro organ culture of VP and SV with recombinant FGF10 protein and/or testosterone.
  • Treatment with anti-androgen (Cyproterone Acetate) to assess androgen receptor involvement.
  • Cell proliferation assays using prostatic and SV cell lines.

    • Main Results:

    • FGF10 transcripts were abundant during early organ formation and neonatal growth, decreasing in quiescent adult organs.
    • FGF10 was expressed in mesenchymal cells, suggesting a paracrine role in epithelial regulation.
    • Recombinant FGF10 stimulated growth of prostatic and SV epithelial cell lines and organ rudiments in vitro.
    • FGF10's effects were independent of androgen receptor signaling.

    Conclusions:

    • FGF10 acts as a mesenchymal paracrine regulator of epithelial growth in the prostate and seminal vesicle.
    • FGF10 plays a significant role in the development of these reproductive organs.
    • FGF10 gene regulation is not directly mediated by androgens in vivo.