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Carotid baroreflex function during prolonged exercise.

K H Norton1, K M Gallagher, S A Smith

  • 1Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, Texas 76107-2609, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 20, 1999
PubMed
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During prolonged exercise, maintaining central venous pressure helps stabilize mean arterial pressure. However, the carotid-cardiac baroreflex becomes ineffective due to progressive resetting, impacting blood pressure regulation.

Area of Science:

  • Exercise Physiology
  • Cardiovascular Regulation
  • Autonomic Nervous System

Background:

  • Prolonged exercise involves complex cardiovascular adjustments.
  • Thermoregulation and central command influence hemodynamic responses.
  • Baroreflex function is crucial for maintaining blood pressure during physical activity.

Purpose of the Study:

  • To differentiate hemodynamic effects of thermoregulation from central command during exercise.
  • To investigate the role of central venous pressure in blood pressure control during prolonged exercise.
  • To examine carotid-cardiac baroreflex resetting during sustained physical exertion.

Main Methods:

  • Subjects performed 1-hour leg cycling with and without dextran infusion to maintain central venous pressure.
Keywords:
NASA Discipline CardiopulmonaryNon-NASA Center

Related Experiment Videos

  • Mean arterial pressure, heart rate, and ratings of perceived exertion were monitored.
  • Carotid-cardiac baroreflex sensitivity was assessed using neck pressure-neck suction technique.

    • Main Results:

    • Volume infusion significantly reduced the drop in mean arterial pressure compared to control.
    • Heart rate and perceived exertion increased similarly in both conditions, indicating consistent central command.
    • Carotid-cardiac baroreflex was progressively reset, shifting its operating point towards the reflex threshold.

    Conclusions:

    • Maintaining central venous pressure attenuates hypotension during prolonged exercise.
    • Central command activation and thermoregulation have distinct effects on hemodynamics.
    • Progressive carotid-cardiac baroreflex resetting renders it ineffective in counteracting exercise-induced hypotension.