Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postnatal hemodynamic changes in very-low-birthweight infants.

T D Yanowitz1, A C Yao, K D Pettigrew

  • 1Department of Pediatrics, Women & Infants' Hospital of Rhode Island, Brown University School of Medicine, Providence, Rhode Island 02905, USA. TYanowitz@mail.magee.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 20, 1999
PubMed
Summary

This study tracked blood flow and heart function in premature infants, finding region-specific changes and adaptations to feeding. Early nutrition initiation positively impacted mesenteric blood flow in very-low-birthweight infants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Morphological diversity of the velamen radicum in the genus Anthurium (Araceae).

Plant biology (Stuttgart, Germany)·2024
Same author

General illness and psychological factors in patients with chronic nasal symptoms.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2017
Same author

Expression and localization of Inter-alpha Inhibitors in rodent brain.

Neuroscience·2016
Same author

Ontogeny of tight junction protein expression in the ovine cerebral cortex during development.

Neuroscience·2015
Same author

The reporting quality of parallel randomised controlled trials in ophthalmic surgery in 2011: a systematic review.

Eye (London, England)·2014
Same author

Short-term outcomes for preterm infants with surgical necrotizing enterocolitis.

Journal of perinatology : official journal of the California Perinatal Association·2014

Area of Science:

  • Neonatal physiology
  • Cardiovascular research
  • Pediatric hemodynamics

Background:

  • Very-low-birthweight infants experience significant physiological changes postnatally.
  • Understanding regional blood flow velocity (BFV) and cardiac function is crucial for optimizing care.

Purpose of the Study:

  • To characterize postnatal hemodynamic changes in very-low-birthweight infants.
  • To investigate factors influencing these hemodynamic alterations, including feeding and ductus arteriosus patency.

Main Methods:

  • Doppler blood flow velocity (BFV) and cardiac function were measured in 20 infants at multiple time points.
  • Measurements included middle cerebral and superior mesenteric artery BFV, cardiac output, stroke volume, and fractional shortening.
  • Hemodynamic parameters were assessed at 6, 30, and 54 hours post-birth and before/after feedings on days 7 and 14.

Related Experiment Videos

Main Results:

  • Postnatal increases in cerebral BFV, mesenteric BFV, and cardiac output were observed, independent of blood pressure, hematocrit, or blood gas levels.
  • Relative vascular resistance (RVR) decreased in the middle cerebral artery but not the superior mesenteric artery.
  • Feeding increased mesenteric BFV and stroke volume, while decreasing mesenteric RVR and heart rate; early enteral nutrition initiation improved mesenteric hemodynamics.

Conclusions:

  • Systemic, cerebral, and mesenteric hemodynamics show region-specific changes in the first week of life for very-low-birthweight infants.
  • Physiological ductus arteriosus patency and early feeding initiation did not significantly alter these postnatal hemodynamic patterns.
  • Cardiac function adapts to enhance mesenteric blood flow in response to feedings, with early nutrition positively influencing mesenteric hemodynamics.