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Skeletal and extraskeletal myxoid chondrosarcoma: related or distinct tumors?
1Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Advances in Anatomic Pathology
|July 20, 1999
Abstract:
Skeletal myxoid chondrosarcoma is a histologic variant of conventional skeletal myxoid chondrosarcoma, whereas extraskeletal myxoid chondrosarcoma is a distinct entity characterized by a reciprocal t(9;22) translocation resulting in fusion of the EWS and CHN genes. Rarely, extraskeletal myxoid chondrosarcoma can occur in bone, and it is difficult to describe such tumors, unambiguously, using the present nomenclature. Designation as "chordoid sarcoma of bone" would distinguish these cases from conventional skeletal myxoid chondrosarcoma.