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Related Experiment Videos

Hepatotoxicity possibly caused by amphotericin B.

J Gill1, H R Sprenger, E D Ralph

  • 1Program in Internal Medicine, University of Western Ontario, London, Canada.

The Annals of Pharmacotherapy
|July 20, 1999
PubMed
Summary

A patient with pulmonary blastomycosis experienced liver damage from amphotericin B. Stopping the medication rapidly resolved the liver issues, suggesting a potential drug interaction with itraconazole.

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Area of Science:

  • Mycology
  • Pharmacology
  • Hepatology

Background:

  • Pulmonary blastomycosis is a serious fungal infection.
  • Amphotericin B is a common antifungal treatment.
  • Hepatotoxicity is a rare but serious side effect of amphotericin B.

Observation:

  • A 26-year-old male with severe pulmonary blastomycosis developed elevated liver enzymes after starting amphotericin B alongside itraconazole.
  • Liver biopsy confirmed drug-induced changes, with no signs of blastomycosis.
  • Discontinuation of amphotericin B led to rapid resolution of liver enzyme elevation.

Findings:

  • This case highlights an uncommon instance of amphotericin B-induced hepatotoxicity.
  • A potential drug interaction between amphotericin B and itraconazole is suggested.

Related Experiment Videos

  • Successful treatment of blastomycosis was achieved with itraconazole alone after amphotericin B was stopped.

    • Implications:

    • Clinicians should be vigilant for hepatotoxicity in patients treated with amphotericin B.
    • Close monitoring of liver enzymes is recommended, particularly when co-administering azole antifungals.
    • This case underscores the importance of considering drug interactions in antifungal therapy.