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Famotidine in the management of schizophrenia
1Department of Pharmacy, Veterans Affairs Chicago Health Care System, IL 60625, USA. maribeth3@hotmail.com
Objective:
To evaluate the use and potential benefit of famotidine in the management of schizophrenia.
Data Sources:
Clinical literature accessed through MEDLINE (February 1998-October 1998). Key search terms included famotidine, schizophrenia, and histamine.
Data Synthesis:
Schizophrenia is a complicated disorder associated with high morbidity if left unmanaged. Histamine2 (H2)-antagonists may be an alternative to conventional treatments. An evaluation of studies focusing on famotidine in the management of schizophrenic symptoms was conducted.
Conclusions:
Famotidine can improve schizophrenic symptoms that were otherwise refractory to typical antipsychotic agents. Further studies should be conducted to determine if other H2-antagonists are also effective.