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Nephrotoxicity in snake envenomation.

V Sitprija1, N Chaiyabutr

  • 1Queen Saovabha Memorial Institute, Bangkok, Thailand.

Journal of Natural Toxins
|July 20, 1999
PubMed
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Snake bites can cause a range of kidney problems, from mild changes to acute renal failure. Understanding these renal manifestations is crucial for effective treatment of snake envenomation.

Area of Science:

  • Nephrology
  • Toxicology
  • Herpetology

Background:

  • Snake envenomation presents a wide spectrum of potential renal complications.
  • Renal involvement can range from subclinical findings to severe acute renal failure.

Purpose of the Study:

  • To comprehensively review the renal manifestations of snake envenomation.
  • To elucidate the pathological mechanisms underlying kidney damage in snake bites.

Main Methods:

  • Literature review of studies on snake envenomation and renal pathology.
  • Analysis of clinical and pathological findings in affected patients.

Main Results:

  • Renal manifestations include proteinuria, hematuria, hemoglobinuria, and myoglobinuria.

Related Experiment Videos

  • Acute renal failure is a significant complication, often involving tubular necrosis.
  • Mesangial proliferative glomerulonephritis is a common pathological finding.

    • Conclusions:

    • Snake venom can directly and indirectly damage all renal structures.
    • Hemodynamic alterations, immune responses, and direct nephrotoxicity contribute to renal lesions.
    • Prompt recognition and management of renal involvement are vital in snakebite victims.