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[Neuromuscular diseases with eosinophilia]
J F Pellissier1, D Figarella-Branger, G Serratrice
1Laboratoire de Biopathologie Nerveuse et Musculaire (JE2053), Faculté de Médecine, Marseille, France. jfpellis@ap-hm.fr
Medecine Tropicale : Revue Du Corps De Sante Colonial
|July 20, 1999
Summary
Neuromuscular diseases with eosinophilia involve muscle, nerve, and connective tissue issues, characterized by eosinophilic infiltration. Muscle biopsy is key for diagnosing these conditions, including Shulman syndrome and eosinophilic myositis.
Area of Science:
- Neurology
- Immunology
- Pathology
Context:
- Neuromuscular diseases encompass a spectrum of disorders affecting muscles, peripheral nerves, and connective tissues.
- Eosinophilic infiltration in blood and/or tissue is a unifying characteristic across these conditions.
- These diseases present distinct clinical and pathological features, requiring precise diagnosis.
Purpose:
- To delineate the various forms of neuromuscular diseases associated with eosinophilia.
- To highlight the diagnostic significance of eosinophilic infiltration.
- To differentiate key conditions such as Shulman syndrome, eosinophilic myositis, and eosinophilic polymyositis.
Summary:
- Neuromuscular disorders with eosinophilia include diffuse fasciitis (Shulman syndrome), eosinophilic myositis, and eosinophilic polymyositis (a manifestation of essential hypereosinophilic syndrome).
- Distinct entities like eosinophilia-myalgia syndrome and toxic oil syndrome, linked to L-tryptophan and adulterated oil ingestion respectively, are also discussed.
- The definitive diagnostic method for these conditions is a muscle biopsy, which reveals the presence of polynuclear eosinophils.
Impact:
- Provides a clear classification of eosinophilic neuromuscular diseases.
- Emphasizes the critical role of muscle biopsy in accurate diagnosis.
- Aids clinicians in differentiating these often severe conditions and guiding appropriate management strategies.