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A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
Published on: May 10, 2013
Urinary platelet-activating factor excretion is elevated in non-insulin dependent diabetes mellitus
1Department of Clinical Laboratory Sciences, School of Allied Health Sciences, University of Texas Health Science Center at San Antonio 78284-7772, USA. kudolo@uthscsa.edu
Prostaglandins & Other Lipid Mediators
|July 20, 1999
Summary
Platelet-activating factor (PAF) may be an early indicator of diabetic nephropathy. Increased urinary PAF levels in non-insulin dependent diabetes mellitus (NIDDM) patients suggest kidney injury precedes microalbuminuria, offering a new diagnostic marker.
Area of Science:
- Nephrology
- Endocrinology
- Biochemistry
Background:
- Diabetic nephropathy is a major complication of diabetes mellitus.
- Proteinuria is a key predictor, but some patients with normal albumin excretion show early kidney damage.
- Platelet-activating factor (PAF) is implicated in vascular permeability and inflammation.
Purpose of the Study:
- To investigate urinary PAF excretion in Mexican-American subjects with non-insulin dependent diabetes mellitus (NIDDM).
- To determine if PAF levels correlate with microalbuminuria and can predict early kidney injury in NIDDM patients.
Main Methods:
- Compared urinary PAF levels in NIDDM patients and healthy controls.
- Measured fasting plasma glucose, insulin, C-peptide, and hemoglobin A1c.
- Assessed urinary albumin excretion (UAE) rates.
Main Results:
- NIDDM subjects exhibited significantly higher urinary PAF excretion compared to controls.
- Urinary PAF levels correlated positively with microalbuminuria (r=0.7), particularly at UAE rates > 30 mg/day.
- Some NIDDM patients with normal UAE still showed elevated urinary PAF, indicating potential early kidney damage.
Conclusions:
- Urinary PAF excretion may precede microalbuminuria in NIDDM patients.
- PAF could serve as a sensitive biomarker for detecting subclinical renal injury in diabetes.
- PAF may link various components of the insulin resistance syndrome.
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