Immunopathology of the human hair follicle

Although patients are told that, in many instances, their hair loss is precipitated by stress, they are certainly stressed and saddened by their alopecia. They would be elated with the ability to regrow their hair. Ideally, therapy would be specific and targeted at the cascade of inflammatory, cytokine-mediated, and mesenchymal events which lead to hair loss. Such is the case with infectious folliculitides: Pityrosporum folliculitis is cleared with antifungal agents, bacterial folliculitis is cleared with antibiotics, and herpetic folliculitis is treated with antiviral agents. Future studies of the hair follicle will perhaps unlock the mechanisms that drive and maintain normal hair growth. Until that time scientists will, no doubt, continue to be fascinated by the intricate developmental and immunologic mechanisms that drive this micro-organ of the skin.