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Leg ulcers and hydroxyurea: forty-one cases.

M E Sirieix1, C Debure, N Baudot

  • 1Rééducation Vasculaire, Hôpital Broussais, Paris, France. marie-emmanuelle.sirieix-h@brs.ap-hop-paris.fr

Archives of Dermatology
|July 20, 1999
PubMed
Summary

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Hydroxyurea therapy for myeloproliferative disorders can cause leg ulcerations. Stopping treatment led to rapid healing in most patients, suggesting hydroxyurea

Area of Science:

  • Dermatology
  • Hematology
  • Pharmacology

Background:

  • Hydroxyurea is an antitumor agent for myeloproliferative disorders.
  • Leg ulcerations are a reported adverse effect of long-term hydroxyurea therapy.
  • Understanding the pathophysiology of hydroxyurea-induced leg ulcers is crucial.

Purpose of the Study:

  • To define the dermatological adverse effect of hydroxyurea therapy.
  • To investigate the pathophysiological process of hydroxyurea-induced leg ulcerations.

Main Methods:

  • Multicenter retrospective study.
  • Collected medical information from 41 patients (mean age 67) with leg ulcerations during hydroxyurea therapy (mean duration 5 years).
  • Assessed hematologic abnormalities and patient outcomes after treatment cessation.

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Main Results:

  • Leg ulcerations developed in 41 patients undergoing hydroxyurea therapy.
  • No underlying vascular disease was identified in affected patients.
  • Complete recovery from ulcerations occurred rapidly after discontinuing hydroxyurea in 80% of cases.

Conclusions:

  • Hydroxyurea therapy is confirmed as a cause of leg ulcerations.
  • Cessation of hydroxyurea treatment is necessary for healing.
  • Potential mechanisms include cutaneous atrophy, impaired wound healing, and poor circulation of megaloblastic erythrocytes.